The Epigenetics Revolution: How Modern Biology is Rewriting Our Understanding of Genetics, Disease and Inheritance

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Carey's achievement is an up-to-date account of an important aspect of modern molecular biology, written with dry humour, peppered with historical anecdotes, sometimes challenging, but always clear and insightful.

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He would have demonstrated beyond doubt that when cells differentiate, their genetic material isn’t irreversibly lost or changed. Photograph: MICHAEL KOOREN/REUTERS Nectar points … bees have phenomenal memories for such small creatures. I relished the opportunity to apply my knowledge of genetics and learn about biological processes in greater detail. It’s a kind of autobiography that presents a harrowing account of the author’s troubled life, especially as a helpless child. But as we shall see, for a scientist as wonderful as John Gurdon, memory is much less important than imagination.Nessa Carey has a PhD in virology from the University of Edinburgh and was formerly a senior lecturer in molecular biology at Imperial College, London. I think of myself of someone who has had a lot of careers in science, rather than one scientific career. The Epigenetics Revolution' is, to my knowledge, the first popular science book that tackles in depth the subject of its title. This section builds upon basic concepts with more advanced theory which might become challenging for some inexperienced readers.

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Unlike the genome, which has been completely deciphered, we still don’t know everything about the epigenome, particularly as far as cancer is concerned.Carey] provides an excellent and largely accurate account of a fascinating and fast-moving area of modern biology.

The Epigenetics Revolution by Nessa Carey | Perlego [PDF] The Epigenetics Revolution by Nessa Carey | Perlego

This is reflected also in the mounting discourse on the societal implications of epigenetics, in which vast expectations coexist with significant uncertainty about what aspects of this science are most relevant for politics or policy alike. Conducting a survey of the twenty-year history of the field while also showcasing its latest findings, this volume provides a solid introduction for grasping the foundations of epigenetics, the field’s recent discoveries and innovations, and its practical and theoretical applications. The beauty of this approach is that just one such toad would topple the entire theory – and topple it he did.

But what sets us apart is the amount of DNA that we have that does not code for proteins: some 98% versus 75% for C. Published in the United Kingdom in 2011 and widely praised on both sides of the Atlantic, this new book is sure to become a classic in modern biology. Carey describes the controversy and politics around this field: "At one extreme we have scientists claiming experimental proof is lacking to support sometimes sweeping claims.

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and] contributes to all sorts of situations, from the correct control of gene expression in female cells to the regulation of pathways that drive cancer. Chapters 3 and 4 give an overview of genetic and epigenetic molecular biology, including the genetic code, DNA replication, transcription, translation, chromatin, DNA methylation, and histone modifications.

We are introduced to the trailblazing work of John Gurdon, whose early work led to the technology used to create Dolly, the famous and arthritic sheep.